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- Title
Optimization of Keyhole Imaging Parameters for Glutamate Chemical Exchange Saturation Transfer MRI at 7.0 T.
- Authors
Lee, Dong-Hoon; Lee, Do-Wan; Woo, Chul-Woong; Kwon, Jae-Im; Kim, Jeong Kon; Kim, Kyung Won; Woo, Dong-Cheol
- Abstract
<bold>Purpose: </bold>To evaluate the effects of a reference image and keyhole factor (Kf) selections for high-frequency substitution on keyhole imaging technique for applications in glutamate chemical exchange saturation transfer (GluCEST) imaging.<bold>Procedures: </bold>The CEST data were obtained using a 7.0 T MRI scanner. We used varied Kf ranges that constituted from 16.67 to 75 % of the full k-space. The reference image was respectively selected for - 3 and + 3 ppm images that associated with the GluCEST calculation and the unsaturated image. The zero-padding algorithm was applied for the missing k-space lines in the low-frequency data collected to compare the results obtained from using the keyhole imaging technique. All the techniques were evaluated using a healthy rat group and extended to the status epilepticus rat group to explore their applicability and usability.<bold>Results: </bold>The calculated GluCEST signals and visually inspected results from the reconstructed GluCEST maps indicated that the combination of unsaturated image as a reference image, and over 50 % of Kf showed consistent signals and image quality compared with the fully sampled CEST data.<bold>Conclusions: </bold>Combining the keyhole imaging technique with GluCEST imaging enables stable image reconstruction and quantitative evaluation, and this approach is potentially applicable in various CEST imaging applications.
- Subjects
MAGNETIZATION transfer; GLUTAMIC acid; STATUS epilepticus; IMAGE reconstruction; ALGORITHMS
- Publication
Molecular Imaging & Biology, 2020, Vol 22, Issue 4, p924
- ISSN
1536-1632
- Publication type
journal article
- DOI
10.1007/s11307-019-01461-z