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- Title
On the Representativeness Assumption in Prevalence Tests of Carcinogenicity.
- Authors
Lagakos, S.W.; Ryan, Louise M.
- Abstract
SUMMARY Conditions for the validity of the Hoel-Walburg and Peto tests, which compare dose groups with respect to tumour prevalence, are replaced by a more general condition, representativeness. A large carcinogenicity experiment provided a unique opportunity to assess empirically if this condition holds. Though representativeness was generally violated, neither the Hoel-Walburg nor the Peto tests were seriously distorted. Analytic considerations suggest that such robustness can occur in many situations.
- Subjects
CARCINOGENICITY testing; CANCER research; TUMORS
- Publication
Journal of the Royal Statistical Society: Series C (Applied Statistics), 1985, Vol 34, Issue 1, p54
- ISSN
0035-9254
- Publication type
Article
- DOI
10.2307/2347885