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- Title
Influence of Genetic Interactions on Polygenic Prediction.
- Authors
Zhijun Dai; Nanye Long; Wen Huang
- Abstract
Prediction of phenotypes from genotypes is an important objective to fulfill the promises of genomics, precision medicine and agriculture. Although it's now possible to account for the majority of genetic variation through model fitting, prediction of phenotypes remains a challenge, especially across populations that have diverged in the past. In this study, we designed simulation experiments to specifically investigate the role of genetic interactions in failure of polygenic prediction. We found that non-additive genetic interactions can significantly reduce the accuracy of polygenic prediction. Our study demonstrated the importance of considering genetic interactions in genetic prediction.
- Subjects
SIMULATION methods &; models; INDIVIDUALIZED medicine; PRECISION farming
- Publication
G3: Genes | Genomes | Genetics, 2020, Vol 10, Issue 1, p109
- ISSN
2160-1836
- Publication type
Article
- DOI
10.1534/g3.119.400812