We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
COVID-19 Olgularında Yoğun Bakım Gereksiniminin Değerlendirilmesinde Tiyol ve İskemi Modifiye Albuminin Rolü.
- Authors
EREN, Funda; NEŞELİOĞLU, Salim; OĞUZ, Esra FIRAT; FIRAT, Rıdvan; İNAN, Osman; GEMCİOĞLU, Emin; ŞAHİNER, Enes Seyda; ATEŞ, İhsan; EREL, Özcan
- Abstract
Background: Corona virus disease (COVID-19) is a global public health problem that has killed more than 4.5 million people. In this study, it was aimed to evaluate the relationship between the thiol and ischemia modified albumin (İMA) levels of COVID-19 patients treated in the inpatient and intensive care unit with their current clinical status. Materials and Methods: In this study, 300 patients who were confirmed to be positive by PCR test and diagnosed with COVID-19 infection were included. The patients were divided into two groups based on the unit they were treated. 160 of these patients were treated in the inpatient service (group 1) and 140 in the intensive care units (group 2). Thiol, İMA, CRP and ferritin levels were measured from the serum samples of the patients. Results: When the groups were compared, the thiol levels of group 2 were found to be significantly lower (p<0.001). In addition, it was observed that the İMA levels of group 2 were significantly higher than group 1 (p<0.001). When other laboratory tests were evaluated, the CRP and ferritin levels of group 2 were high (p<0.001) and the lymphocyte count was low (p<0.001). A significant correlation was found between thiol levels and CRP, ferritin, lymphocyte and İMA levels ( r=-0,58, p<0,001; r=-0,41, p<0,001; r=0,32, p<0,001; r=-0,39, p<0,001, respectively). In addition, a significant correlation was observed between İMA levels and CRP, ferritin, lymphocyte and thiol levels (r=0,19, p=0,02; r=0,18, p=0,043; r=-0,15, p=0,047; r=-0,39, p<0,001, respectively). Conclusions: The decrease in the level of thiol, which is a powerful antioxidant, in COVID-19 patients suggests that although it is due to the existing inflammatory process that causes oxidative stress, it may also be caused by the effect of oxidative stress due to ischemic conditions developing secondary to thrombosis. Therefore, the increase in İMA levels in intensive care patients in whom the inflammatory process and thrombotic events are observed more severely supports the decrease in thiol levels. As a result, the determination of thiol and İMA levels of COVID-19 patients treated in the inpatient and intensive care unit suggests that it has the potential to help with the current clinical status of the patients and the course of the disease.
- Subjects
ALBUMINS; INTENSIVE care units; SULFUR compounds; C-reactive protein; CLINICAL pathology; COVID-19; FERRITIN; ANTIOXIDANTS; OXIDATIVE stress; HOSPITAL care; POLYMERASE chain reaction; LYMPHOCYTE count
- Publication
Journal of Harran University Medical Faculty / Harran Üniversitesi Tıp Fakültesi Dergisi, 2022, Vol 19, Issue 1, p126
- ISSN
1304-9623
- Publication type
Article
- DOI
10.35440/hutfd.1068150