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- Title
Mosaic TP53 Mutation on Tumour Development in Pigs: A Case Study.
- Authors
Thongkittidilok, Chommanart; Hirata, Maki; Lin, Qingyi; Torigoe, Nanaka; Liu, Bin; Sato, Yoko; Nagahara, Megumi; Tanihara, Fuminori; Otoi, Takeshige
- Abstract
Pigs rarely develop cancer; however, tumour protein p53 (TP53)-modified pigs may have an increased incidence of cancer. In this study, two pigs with mosaic mutations induced by gene editing were compared to determine the role of the wild-type TP53 sequence in tumorigenesis and to speculate how amino acid changes in TP53 sequences are related to tumorigenesis. The pig without tumours had a wild-type TP53 sequence and a 1-bp deletion in the TP53 sequence that resulted in a premature stop codon. In contrast, the pig with nephroblastoma had 6- and 7-bp deletions in the TP53 sequence, resulting in the absence of two amino acids and a premature stop codon, respectively. Our results indicated that TP53 mutations with truncated amino acids may be related to tumour formation.
- Subjects
SWINE; P53 protein; GENOME editing; GENETIC mutation; AMINO acids; BEGOMOVIRUSES
- Publication
Veterinary Medicine International, 2023, p1
- ISSN
2090-8113
- Publication type
Article
- DOI
10.1155/2023/7000858