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- Title
Serum cystatin C and mild cognitive impairment: The mediating role of glucose homeostasis.
- Authors
Kai Li; Jing Xu; Meiduo Zhao; Yayuan Mei; Quan Zhou; Jiaxin Zhao; Yanbing Li; Ming Yang; Qun Xu
- Abstract
Background: This study explored the mediating role of glucose homeostasis indicators in the relationship between serum cystatin C and mild cognitive impairment (MCI). Methods: The present study used a cross-sectional design and included 514 participants aged ≥50 years in Beijing, China. The Mini-Mental State Examination was used to assess cognitive function. Serum cystatin C and a comprehensive set of glucose homeostasis indicators were detected, including fasting blood glucose (FBG), glycosylated albumin percentage (GAP), glycated hemoglobin (HbAlc), insulin, and homeostatic model assessment of insulin resistance (HOMAIR), and beta cell function (HOMA-b). Generalized linear models were used to investigate the associations among cystatin C, glucose homeostasis indicators, and cognitive function. Mediation analysis was conducted to explore potential mediator variables. Results: In this study of 514 participants, 76 (14.8%) had MCI. Those with cystatin C levels ≥1.09 mg/L had a 1.98-fold higher risk of MCI than those with levels <1.09 mg/L (95% CI, 1.05-3.69). FBG, GAP, and HbA1c increased the risk of MCI, while HOMA-b decreased the risk. Notably, the associations between MCI risk and cystatin C or glucose homeostasis were only founded in diabetes patients. Serum cystatin C was found to be positively associated with HOMA-b (beta (95% CI): 0.20 [0.06, 0.34]), HOMA-IR (0.23 [0.09, 0.36]), and insulin (0.22 [0.09, 0.34]) levels. Moreover, HOMA-b was identified as playing a negative mediating role (proportion mediated: 16%) in the relationship between cystatin C and MCI. Conclusion: Elevated levels of cystatin C are associated with an increased risk of MCI. The glucose homeostasis indicator, HOMA-b, plays a negative mediating role in the relationship between cystatin C and MCI risk.
- Subjects
CHINA; RISK factors of mild cognitive impairment; HOMEOSTASIS; ALBUMINS; GLYCOSYLATED hemoglobin; CONFIDENCE intervals; SERUM; CROSS-sectional method; BLOOD sugar; COGNITION; HYPOGLYCEMIC agents; RISK assessment; INSULIN; FACTOR analysis; DESCRIPTIVE statistics; RESEARCH funding; QUESTIONNAIRES; BODY mass index; CYSTATIN C; INSULIN resistance
- Publication
Frontiers in Aging Neuroscience, 2023, Vol 15, p1
- ISSN
1663-4365
- Publication type
Article
- DOI
10.3389/fnagi.2023.1102762