We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
TiO<sub>2</sub> particles induce ER stress and apoptosis in human hepatoma cells, HepG2, in a particle size-dependent manner.
- Authors
Song, Ha Na; Jang, Su Kyung; Hwang, Ok Kyung; Lee, Hong Jin; Chun, Hyang Sook
- Abstract
The cytotoxicity of TiO2 nanoparticles are well-known, but the particle size-dependent induction of ER stress and apoptosis by TiO2 in hepatocytes has not been elucidated clearly. In the present study, we investigated whether a fine TiO2 particle and two types of TiO2 nanoparticles induce ER stress and apoptosis differently in HepG2 cells. A particle size-dependent decrease in cell viability was observed after exposure to the TiO2 particles. The levels of ER stress-related proteins (BiP, CHOP, ATF6α, and p-PERK) were increased with decreasing particle size. TiO2 particles induced ER stress-mediated apoptosis in a particle size-dependent manner as seen by a decrease in the expression of Bcl-2, and increases in the expression of Bax, caspase-12, and cleaved caspase-3. These results indicated that the cytotoxicity produced by TiO2 particles was related to particle size, with smaller TiO2 nanoparticles producing greater toxic effects involving ER stress and apoptosis in the HepG2 cells.
- Publication
Food Science & Biotechnology, 2019, Vol 28, Issue 6, p1907
- ISSN
1226-7708
- Publication type
Article
- DOI
10.1007/s10068-019-00623-7