We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Fractionated stereotactic radiosurgery for intracranial metastases: tumor control.
- Authors
Katz, J. S.; Kushnirsky, M.; Knisely, J.; Schulder, M.; Ghaly, M.
- Abstract
Purpose: Fractionated SRS may confer radiobiologic treatment advantages in the eradication of metastatic brain tumors. We compared the results of single and fractionated SRS for patients with metastatic tumors. Methods: We reviewed all patients from our institution who were treated with SRS for intracranial metastases between January 2010 and September 2012. Collected data included diagnosis, tumor location, lesion volume, and SRS dose. Local control (LC) and volume changes after fractionated or single fraction SRS were compared using t-test and chi-square test. Results: 152 patients with 279 lesions underwent SRS. 214 lesions were available for followup with serial MRI from 0.2 -24.5 months (5.00 ± 6.73 months) after SRS, with overall LC of 76%. 63 lesions had treatment volumes greater than 3 cc. Of these, 31 lesions underwent single session SRS and 32 were treated in 3 sessions. Median prescription doses for single and fractionated SRS were 20 Gy and 24 Gy, respectively. Tumor progression was observed in 9/31 lesions treated with a single session, compared with progression in only 1/32 lesion treated with 3 sessions (chi-square = 0.004). Overall, lesion volume following fractionated SRS decreased by 66.6%, vs. a 66.3% decrease after single session SRS (p = 0.95). Conclusion: Fractionated SRSforpatients with metastatic brain tumors yielded volumetric decrease in tumor size that was equivalent to that obtained with single session SRS. For larger tumors, LC was significantly better in patients treated with fractionated SRS. We recommend consideration of fractionated SRS for patients with metastatic tumors larger than 3 cc. Disclosure: No significant relationships.
- Subjects
RADIOBIOLOGY research; BRAIN metastasis; BRAIN tumors; TUMOR classification; STEREOTACTIC radiosurgery
- Publication
Journal of Radiosurgery & SBRT, 2013, Vol 2, p18
- ISSN
2156-4639
- Publication type
Article