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- Title
Laboratory Parameters Predicting Brain Metastasis in Patients with Lung Cancer.
- Authors
TUĞRUL, Fuzuli; BEYPINAR, İsmail; UÇAN, Anıl
- Abstract
OBJECTIVE Lung cancer (LC) is the leading cause of cancer death worldwide. Multiple studies have shown tumor progression and prognosis to be associated with immune status and nutritional condition. Alterations in blood lipid levels have been demonstrated to be a risk factor for LC. In the present study, we evaluate the effect of blood parameters on brain metastasis in LC. METHODS Patients identified with brain metastases during diagnosis or therapy and who subsequently underwent radiation therapy were included in the study. Patient characteristics, laboratory parameters, pathologic subtype, disease stage, treatment modalities, and outcome following treatment were recorded, and the patients' PFS and OS were calculated. RESULTS Univariate analysis revealed neutrophil, low-density lipoprotein (LDL), neutrophil-to-lymphocyte ratio (NLR), and C-reactive protein levels to be significantly different between groups according to brain metastases. In a subgroup analysis based on cancer subtypes, LDL and lymphocyte levels were found to be significantly different in squamous cancer, while LDL was different in the undifferentiated subtype. OS was different in the NLR low and high groups, favoring the NLR low group (p=0.015; OS: 12 vs. 9 months), and the monocyte/lymphocyte ratio was significant in terms of OS favoring the low group with a cutoff value of 0.56 (p=0.002; OS: 13 vs. 9 months). CONCLUSION Our study identified differences in the inflammatory and lipid profiles of LC patients in terms of brain metastases and survival. Other than the literature, LDL levels were different among groups and may be considered a valid subject for future study.
- Subjects
BRAIN tumor risk factors; RISK assessment; NEUTROPHIL lymphocyte ratio; SQUAMOUS cell carcinoma; ADENOCARCINOMA; RECEIVER operating characteristic curves; NEUTROPHILS; LIPIDS; TUMOR markers; CANCER patients; RETROSPECTIVE studies; LYMPHOCYTES; CHI-squared test; MULTIVARIATE analysis; METASTASIS; LONGITUDINAL method; LOW density lipoproteins; MONOCYTE lymphocyte ratio; KAPLAN-Meier estimator; LUNG tumors; MEDICAL records; ACQUISITION of data; URBAN hospitals; STATISTICS; PROGRESSION-free survival; INFLAMMATION; DATA analysis software; LUNG cancer; SMALL cell carcinoma; COMPARATIVE studies; OVERALL survival; C-reactive protein; SERUM albumin
- Publication
Turkish Journal of Oncology / Türk Onkoloji Dergisi, 2024, Vol 39, Issue 1, p63
- ISSN
1300-7467
- Publication type
Article
- DOI
10.5505/tjo.2023.3943