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- Title
Advances of nanoparticles in transmucosal drug delivery.
- Authors
Zhang, Li; Yang, Changwei; Song, Yingxiang; Sheng, Tao; Li, Junyan; Yu, Jicheng; Wu, Xiaohong; Ye, Xiao
- Abstract
Transmucosal drug administration represents a potential strategy for enhancing treatment efficacy and reducing side effects by avoiding the first-pass effect into the systemic circulation and delivering therapeutics directly to the target disease site. However, many challenges still remain in its clinical application, including low drug availability and limited retention time in the mucosa. The burgeoning advancement of nanotechnologies offers great potential to overcome the above limitations, leveraging their distinct advantages of high drug-loading capacity and strong permeability. In this review, the latest developments of nanoparticles (NPs) in transmucosal drug delivery as well as their clinical applications are discussed.
- Subjects
DRUG accessibility; DRUG bioavailability; NANOPARTICLES; RF values (Chromatography); TREATMENT effectiveness; DRUG delivery systems
- Publication
Nano Research, 2024, Vol 17, Issue 4, p2874
- ISSN
1998-0124
- Publication type
Article
- DOI
10.1007/s12274-023-6188-7