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- Title
The relationship between dyspnea and blood oxygen saturation.
- Authors
McKenzie, Erin; Liying Zhang; Zaki, Pearl; Chan, Stephanie; Drost, Leah; Yee, Caitlin; Razvi, Yasmeen; Tsao, May; Barnes, Elizabeth; DeAngelis, Carlo; Chow, Edward
- Abstract
Dyspnea is a common and debilitating symptom experienced by advanced cancer patients that significantly detracts from quality of life. The relationship between dyspnea and blood oxygen saturation has been hypothesized, with the literature presenting conflicting results. Our study sought to better define this complex relationship. A prospective database was analyzed to extract patient demographics and dyspnea scores using the ESAS shortness of breath item to classify mild (1-3), moderate (4-6) and severe (7-10) dyspnea. Univariate logistic regression analysis and generalized estimating equations (GEE) were used to identify correlations of pulse oximetry <90% and hemoglobin <100 g/L with the presence of dyspnea (ESAS ≥ 1), severity of dyspnea (none, mild, moderate, severe), and presence of moderate/severe dyspnea (ESAS ≥ 4) at patients' first visit and over time, respectively. The analyses showed pulse oximetry < 90% was significant for all analyses over time and for the increased severity of dyspnea at the first visit (p < 0.05). Hemoglobin < 100 g/L was not significant for any analysis results. The relationship between dyspnea and blood oxygen saturation is complex and treatment targeting physiological changes in blood oxygen may not generate significant clinical benefit, although perceived benefit in quality of life may be achieved.
- Subjects
REACTIVE oxygen species; CANCER patients; DYSPNEA; HEMOGLOBINS; MEDICAL records; OXIMETRY; OXYGEN; OXYGEN in the body; QUALITY of life; PULSE oximeters; LOGISTIC regression analysis; SEVERITY of illness index; ACQUISITION of data methodology
- Publication
Journal of Pain Management, 2019, Vol 12, Issue 2, p109
- ISSN
1939-5914
- Publication type
Article