The article discusses the study conducted by S. Marzian and colleagues on the development and structural models of the side pocket binding site for small molecule Psora-4. It states that the new Psora-4 binding site between the pore and the voltage-sensor domain of Kv1.5 was developed through combination of molecular modeling, mutagenesis, and electrophysiology. It adds that Psora-4 molecule can adopt the phenyl ring in the side chain.