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- Title
μ-Opioid Receptor Gene (OPRM1) Polymorphisms A118G and C17T in Alcohol Dependence: A Turkish Sample.
- Authors
GÜREL, Şeref Can; AYHAN, Yavuz; KARAASLAN, Çağatay; AKEL, Hayriye; KARACA, Ragıp Özgür; BABAOĞLU, Melih Önder; YAŞAR, Ümit; BOZKURT, Atilla; DİLBAZ, Nesrin; ULUĞ, Berna Diclenur; DEMİR, Başaran
- Abstract
Objectives: Previous investigations on opioid system genetics have identified polymorphisms of the OPRM1 gene expressing µ-opioid receptors to besignificantly associated with some features of alcohol dependence (AD). In the present study, we evaluated the relationship between single nucleotidepolymorphisms (SNP) in the OPRM1 gene, A118G (rs1799971, Asn40Asp) and C17T (rs1799972, Arg6Val), and AD diagnosis, level of alcoholconsumption, and AD severity in a Turkish sample. Methods: 121 AD patients and 117 healthy male subjects were included in the study. OPRM1 A118G (N40D) and C17T (A6V) polymorphisms were evaluated using PCR - RFLP (polymerase chain reaction - restriction fragment length polymorphism) method. We evaluated the association between the presence of SNPs and AD diagnosis, family history of AD, AD severity evaluated via the Michigan Alcoholism Screening Test (MAST), the daily average and maximum quantity of alcohol consumed. Results: There was no significant difference in OPRM1 A118G genotype frequencies between the AD and control groups. T allele frequency for the OPRM1 C17T SNP was very low (0.006) in the sample population. OPRM1 A118G SNP G118 allele carriers showed significantly higher levels of AD severity as indicated by the MAST. Conclusion: The OPRM1 G118 allele was significantly associated with more severe AD in the Turkish population. Similar to other European populations, the frequency of the OPRM1 T17 allele was very low.
- Subjects
OPIOID receptors; GENETIC polymorphisms; GENE expression; ALCOHOL Dependence Scale; SINGLE nucleotide polymorphisms; POLYMERASE chain reaction; RESTRICTION fragment length polymorphisms
- Publication
Turkish Journal of Psychiatry, 2016, Vol 27, Issue 2, p1
- ISSN
1300-2163
- Publication type
Article
- DOI
10.5080/u12336