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- Title
Parkinson's disease with homozygous PINK1 p.Leu489Pro mutations in two Indian sisters.
- Authors
Shen-Yang Lim; Ahmad-Annuar, Azlina; Lohmann, Katja; Ai Huey Tan; Yi Wen Tay; Jia Lun Lim; Ramli, Norlisah; Pei Chiek Teh; Kuppusamy, Rishikesan; Chong Tin Tan; Khean Jin Goh; Viswanathan, Shanthi; Bauer, Peter; Rolfs, Arndt; Klein, Christine
- Abstract
We describe the clinical features of two sisters with Parkinson's disease (PD) of Indian descent living in Malaysia. Both were homozygous for the known PINK1 mutation p.Leu489Pro (c.1466T>C). The proband, who has been followed up by us over a span of 35 years, had a fairly "classic" clinical presentation for PARK-PINK1, including young onset, a clear response to dopamine replacement therapy, and development of troublesome motor fluctuations and dyskinesias. Her dyskinesias improved substantially with clozapine treatment, which to our knowledge has not specifically been reported for PARK-PINK1; this treatment has been sustained for nearly a decade. The clinical phenotype of the older sister was more akin to later-onset "idiopathic" PD; however, her brain MRI showed abnormal signal in the posterior limb of the internal capsules and the hypothalamus. Our report contributes to the scarce literature on monogenic PD in the Malaysian / Indian population, and further supports the pathogenicity of the PINK1 p.Leu489Pro variant.
- Subjects
MALAYSIA; PARKINSON'S disease; DYSKINESIAS; SISTERS; INDIANS (Asians); PHENOTYPES
- Publication
Neurology Asia, 2021, Vol 26, Issue 1, p167
- ISSN
1823-6138
- Publication type
Article