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- Title
Necrólisis epidérmica tóxica debido a un fármaco a base de caléndula más acetilcisteína: presentación de caso.
- Authors
Rosero-Castro, Diana Elizabeth; Molineros-Gallón, Luis Fernando; Torres-Rivas, Gloria Lucy; Andino-Bucheli, Luis Guillermo; Portillo-Miño, José Darío
- Abstract
Introduction: Drug hypersensitivity is induced by an aberrant response from the immune system. It is usually unpredictable, dose-independent, and can be life-threatening to the patient. Drug-induced hypersensitivity reactions with mucocutaneous involvement occur in approximately 2-3% of hospitalized patients. However, Toxic Epidermal Necrolysis is a rare case. Aim: To describe a case of drug-induced toxic epidermal necrolysis triggered by Calendula officinalis and acetylcysteine. Case report: A 39-year-old male was presented to the emergency room with malaise, arthralgia, myalgia, asthenia, and adynamia since day one. Three days later, he developed progressive purpuric lesions that spread to the face, extremities, and buttocks. These lesions were painless, not delineate, and did not blanch under pressure. They were associated with dyspnea and hemodynamic and cardiovascular instability. On the sixth day of hospitalization, the patient admitted to self-medicating with an unknown drug, presumably a herbal extract based on calendula and acetylcysteine, for arthralgia, myalgia, and dysphagia. The morning after the drug consumption, the patient developed extensive purpuric and ulcerative lesions. A diagnosis of toxic epidermal necrolysis was made based on clinical suspicion and histopathological confirmation. Conclusion: Severe adverse drug reactions that threaten a patient's life are relatively rare. However, they represent a real diagnostic and therapeutic challenge when they do occur.
- Subjects
MYALGIA; CALENDULA officinalis; TOXIC epidermal necrolysis; ASTHENIA; PURPURA (Pathology); SELF medication; ACETYLCYSTEINE; JOINT pain; DYSPNEA; DEGLUTITION disorders; HISTOLOGY; DISEASE risk factors
- Publication
Revista Ciencias de la Salud, 2024, Vol 22, Issue 1, p1
- ISSN
1692-7273
- Publication type
Article
- DOI
10.12804/revistas.urosario.edu.co/revsalud/a.12096