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- Title
A New Ascochlorin Glycoside from Brittlestar-Derived Fungus Acremonium sp. and Its Biological Activities.
- Authors
Zhihong Luo; Kai Liu; Zhenzhou Tang; Liang Peng; Chenghai Gao; Chenxi Xia; Yonghong Liu; Xianqiang Chen
- Abstract
A new ascochlorin glycoside (1) and 8 known ascochlorin derivatives (2-9), and ilicicolin H (10) were purified from brittlestar derived fungus Acremonium sp. GXIMD02024. Their structural elucidations were carried out by analyses of 1D and 2D NMR, high resolution mass spectrometry, and CD spectroscopic data and comparison of those with literature data. Compound 1 was a rare fungal polyketide-sesquiterpenoid possessing sugar moiety. The antibacterial and cytotoxicity activities of compounds 1-10 have been performed in vitro. Compounds 1-3, 7, 8, and 10 were measured for their inhibitory effect on α-glucosidase. Compound 1 exhibited poor activity or was inactive, but the detail analysis indicated sugar moiety in 1 maybe play an important role in effect on biological activities.
- Subjects
ACREMONIUM; GLYCOSIDES; FUNGI; SUGAR analysis; MASS spectrometry; MARINE fungi
- Publication
Records of Natural Products, 2024, Vol 18, Issue 1, p136
- ISSN
1307-6167
- Publication type
Article
- DOI
10.25135/rnp.438.12310.2940