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- Title
Vascular Endothelial Growth Factor-D (VEGF-D) is Elevated in Bronchoalveolar Lavage Fluid of Patients with Lung Squamous Carcinoma.
- Authors
Dan Lv; Lin Tan; Qihe Zhang; Hongying Ma; Yun Zhang; Qiaoli Zhang; Yiming Yu; Zhongbo Chen; Qunli Ding; Zaichun Deng
- Abstract
Background: Previous studies have found that vascular endothelial growth factor (VEGF) is associated with lung cancer, yet little is known about vascular endothelial growth factor-D (VEGF-D) in bronchoalveolar lavage fluid (BALF) of lung cancer patients. In this study, we aim to investigate the expression and evaluation of VEGF-D in BALF for lung cancer diagnosis. Methods: BALF samples were acquired from 81 patients: 40 with benign diseases and 41 with lung cancer. The expression of VEGF-D in BALF was measured using sandwich enzyme-linked immune sorbent assays (ELISA), and the evaluation of VEGF-D in BALF for lung cancer diagnosis was also investigated. Results: In the BALF samples, the levels of VEGF-D in the lung cancer group were higher than in the benign disease group; however, there was no statistical significance between the two groups (p > 0.05). In the pathological classification of lung cancer, the levels of VEGF-D in the BALF differed significantly between the lung squamous carcinoma group and the benign disease group (p < 0.05). The diagnostic accuracies of VEGF-D in BALF for discrimination between patients with squamous cell carcinoma and benign disease were reasonable based on receiver operating characteristic (ROC curve) analysis, with a corresponding sensitivity of 64.7% and specificity of 60%, respectively. Conclusions: This study demonstrated that the detection of VEGF-D levels in BALF is a valuable diagnostic tool for lung squamous carcinoma.
- Subjects
VASCULAR endothelial growth factors; BRONCHOALVEOLAR lavage; SQUAMOUS cell carcinoma; NON-small-cell lung carcinoma; METASTASIS
- Publication
Clinical Laboratory, 2019, Vol 65, Issue 1/2, p125
- ISSN
1433-6510
- Publication type
Article
- DOI
10.7754/Clin.Lab.2018.180712