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- Title
NIR light‐triggered gelling in situ of porous silicon nanoparticles/PEGDA hybrid hydrogels for localized combinatorial therapy of cancer cells.
- Authors
Xia, Bing; Zhang, Weiwei; Shi, Jisen; Li, Jiachen; Chen, Zhenyu; Zhang, Qi
- Abstract
Porous silicon‐based nanocomposite hydrogels were readily constructed with the gelation of poly(ethylene glycol) double acrylates (PEGDA) macromers, due to the initiation of singlet oxygen photosensitized with porous silicon nanoparticles (PSiNPs) under near‐infrared (NIR) light irradiation. Multifunctional PSiNPs/PEGDA nanocomposite hydrogels showed strong fluorescence, excellent biodegradability, significant photothermal effect, and sustained drug release with high efficiency (>80%). Finally, in situ growth of PSiNPs/PEGDA hybrid hydrogels on cancer cells was also achieved by NIR light, and then their biodegradation, drug release and synergistic chemo‐phototherapeutic efficacy were further demonstrated, which could provide a significant localized inhibition for the viability, adherence, and migration of cancer cells in vitro. Thus, we suggested that these resultant hybrid hydrogels would have important potential on local cancer therapy in future clinical practice. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47443. Biodegradable porous silicon nanoparticles/poly(ethylene glycol) double acrylates hydrogels were readily formed in situ on cancer cells by NIR light, which provided localized combination therapeutic efficacy for killing cancer cells in vitro.
- Subjects
SILICON; NANOCOMPOSITE materials; HYDROGELS; GELATION; ACRYLATES
- Publication
Journal of Applied Polymer Science, 2019, Vol 136, Issue 17, pN.PAG
- ISSN
0021-8995
- Publication type
Article
- DOI
10.1002/app.47443