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- Title
Cholesterol's Aliphatic Side Chain Modulates Membrane Properties.
- Authors
Scheidt, Holger A.; Meyer, Thomas; Nikolaus, Jörg; Baek, Dong Jae; Haralampiev, Ivan; Thomas, Lars; Bittman, Robert; Müller, Peter; Herrmann, Andreas; Huster, Daniel
- Abstract
The influence of cholesterol's alkyl side chain on membrane properties was studied using a series of synthetic cholesterol derivatives without a side chain or with a branched side chain consisting of 5 to 14 carbon atoms. Cholesterol's side chain is crucial for all membrane properties investigated and therefore essential for the membrane properties of eukaryotic cells.
- Subjects
MEMBRANE proteins; MEMBRANE lipids; STEROLS; SUBSTITUENTS (Chemistry); PHOSPHOLIPIDS
- Publication
Angewandte Chemie International Edition, 2013, Vol 52, Issue 49, p12848
- ISSN
1433-7851
- Publication type
Article
- DOI
10.1002/anie.201306753