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- Title
Stabilization of Peptides for Intracellular Applications by Phosphoramidate-Linked Polyethylene Glycol Chains.
- Authors
Nischan, Nicole; Chakrabarti, Alokta; Serwa, Remigiusz A.; Bovee‐Geurts, Petra H. M.; Brock, Roland; Hackenberger, Christian P. R.
- Abstract
PEG intracellularly! Although long known to enhance residence half‐life of peptides in serum and lysates, the effect of PEGylation on biological probes in cells has received only limited attention. Here it is shown that phosphoramidate‐linked PEGylated proapoptotic peptides display a dramatically increased stability in Jurkat cell lysate and a homogenous intracellular distribution as well as high apoptotic activity after introduction into cells.
- Subjects
HEPARAN sulfate; OLIGOSACCHARIDES; MULTIENZYME complexes; POLYOLS; PROTEINS
- Publication
Angewandte Chemie International Edition, 2013, Vol 52, Issue 45, p11920
- ISSN
1433-7851
- Publication type
Article
- DOI
10.1002/anie.201303467