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- Title
Substrate Selectivity Analyses of Factor Inhibiting Hypoxia-Inducible Factor.
- Authors
Yang, Ming; Hardy, Adam P.; Chowdhury, Rasheduzzaman; Loik, Nikita D.; Scotti, John S.; McCullagh, James S. O.; Claridge, Timothy D. W.; McDonough, Michael A.; Ge, Wei; Schofield, Christopher J.
- Abstract
Substrate specificity: Biochemical and crystallographic analyses reveal the hypoxia‐inducible factor hydroxylase (FIH) as being promiscuous with respect to the residues that it can hydroxylate in β‐position, which in addition to Asn, Asp, and His include Leu and Ser residues. The Ser substrate is oxidized to an epimeric β‐geminal diol product (see picture).
- Publication
Angewandte Chemie International Edition, 2013, Vol 52, Issue 6, p1700
- ISSN
1433-7851
- Publication type
Article
- DOI
10.1002/anie.201208046