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- Title
Asymmetric Intramolecular Oxa-Michael Reactions of Cyclohexadienones Catalyzed by a Primary Amine Salt.
- Authors
Wu, Wenbin; Li, Xin; Huang, Huicai; Yuan, Xiaoqian; Lu, Junzhu; Zhu, Kailong; Ye, Jinxing
- Abstract
Michael brings the rings: An asymmetric intramolecular oxa‐Michael reaction involving iminium activation has been developed. This reaction provides enantioenriched 1,4‐dioxane derivatives with up to 99 % yield and 98 % ee. The method allows for concise and stereoselective access to stereodiverse, complex tetracyclic compounds containing a bicyclo[2.2.2]octan‐2‐one backbone with multiple chiral centers.
- Publication
Angewandte Chemie International Edition, 2013, Vol 52, Issue 6, p1743
- ISSN
1433-7851
- Publication type
Article
- DOI
10.1002/anie.201206977