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- Title
Transient receptor potential vanilloid (TRPV) channels: Basal properties and physiological potential.
- Authors
Tomohiko Sasase; Fatchiyah, Fatchiyah; Takeshi Ohta
- Abstract
Transient receptor potential vanilloid (TRPV) channels are TRP homologs and have been classified into six subfamilies. They are unique mediators of sensory signals with multiple physiological effects and are potential targets for developing new therapies targeting human diseases. TRPV channels play crucial roles in normal physiological processes, and their dysfunction has been implicated in various disease states. Several small-molecule compounds, such as TRPV1 and TRPV3 antagonists, have been developed as novel analgesic agents. A better understanding of the physiological functions of TRPV channels would lead to progress in life science. In this review, we focus on various functions of TRPV channels, including pain sensing, temperature sensing, and metabolic control, as well as summarize the basal properties and pathophysiological contributions of six TRPV channels. Moreover, we discuss the pharmacological effects of endogenous and exogenous ligands on TRPV channels and related diseases.
- Subjects
LIFE sciences; TRPV cation channels; DRUG discovery; DISEASE progression; TRP channels
- Publication
General Physiology & Biophysics, 2022, Vol 41, Issue 3, p165
- ISSN
0231-5882
- Publication type
Article
- DOI
10.4149/gpb_2022016