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- Title
Infective Endocarditis Due to Optochin-Resistant Streptococcus pneumoniae.
- Authors
Nishiyama, Hideki; Shirayama, Hideo; Asami, Saori; Ikegami, Shinobu; Murakami, Itsuka; Yamagishi, Hiroe; Yuasa, Norihiro; Oba, Taku; Ohkusu, Kiyofumi; Ohta, Michio
- Abstract
Background: Streptococcus species account for 17%-50% of the microorganisms causing infectious endocarditis (IE), but S. pneumoniae rarely causes IE. Most clinical microbiology laboratories today depend on the optochin test to identify pneumococci. However, there have been several reports of optochin-resistant pneumococci. Case Report: A 64-year-old man suffered from sepsis and had a large vegetation on the aortic valve. The bacteria detected in the blood cultures showed α-hemolysis and were optochin-resistant, which suggested that these microorganisms were viridans streptococci. However, the bile solubility test, additional biochemical testing, and genetic analysis by polymerase chain reaction (PCR) revealed that the isolate was S. pneumoniae. Conclusions: Alpha-hemolytic streptococci showing optochin resistance should undergo additional tests before being identified as viridans streptococci, especially if the strain has been isolated from a sterile site in the body, such as the blood or cerebrospinal fluid.
- Subjects
ECHOCARDIOGRAPHY; DIAGNOSIS of endocarditis; PNEUMONIA diagnosis; ENDOCARDITIS; DRUG resistance in microorganisms; MICROBIAL sensitivity tests; PNEUMONIA; POLYMERASE chain reaction; STREPTOCOCCAL diseases
- Publication
Laboratory Medicine, 2011, Vol 42, Issue 9, p536
- ISSN
0007-5027
- Publication type
Article
- DOI
10.1309/LMNSG654NTHJYUFI