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- Title
Sleeve Gastrectomy Reduces Blood Pressure in Obese ( fa/fa) Zucker Rats.
- Authors
Rodríguez, Amaia; Becerril, Sara; Valentí, Víctor; Ramírez, Beatriz; Martín, Marina; Méndez-Giménez, Leire; Lancha, Andoni; Sol Calderón, Pablo; Catalán, Victoria; Burrell, María; Gómez-Ambrosi, Javier; Frühbeck, Gema
- Abstract
Background: Sleeve gastrectomy constitutes an effective surgical procedure for the treatment of morbid obesity in humans and rodents with diet-induced obesity. The aim of the present study was to establish the effects of sleeve gastrectomy on weight loss and cardiovascular parameters in genetically obese ( fa/fa) Zucker rats. Methods: Eleven-week-old male obese ( fa/fa) ( n = 20) Zucker rats were assigned to three alternative procedures (sham operation, sleeve gastrectomy, or pair-fed to the amount of food eaten by sleeve-gastrectomized animals) and compared with lean Zucker ( Fa/Fa) rats ( n = 9). Systolic (SBP), diastolic (DBP), and mean (MBP) blood pressure values as well as heart rate (HR) were recorded in conscious, resting animals by non-invasive tail-cuff plethysmography before and 3 weeks after the surgical interventions. Results: Sleeve-gastrectomized rats experienced a reduction in body weight ( P < 0.01), total adiposity amounts ( P < 0.001), together with an increased excess weight loss (%EWL) ( P < 0.05) compared with sham-operated and pair-fed animals 3 weeks after the surgical interventions. Rats with sleeve gastrectomy exhibited reduced ( P < 0.01) blood pressure values (ΔSBP = −11 ± 8 mmHg; ΔDBP = −6 ± 4 mmHg; ΔMBP = −8 ± 6 mmHg) compared with the control group, but no changes were observed in HR ( P = 0.560). Sham-operated and pair-fed groups did not alter their cardiovascular variables. Conclusions: Our findings provide evidence of the beneficial effects of sleeve gastrectomy on blood pressure values in addition to the weight loss in obese ( fa/fa) Zucker rats independently of surgical trauma and food intake reduction.
- Subjects
GASTRECTOMY; STOMACH surgery; OBESITY; ZUCKER rats; PLETHYSMOGRAPHY
- Publication
Obesity Surgery, 2012, Vol 22, Issue 2, p309
- ISSN
0960-8923
- Publication type
Article
- DOI
10.1007/s11695-011-0562-3