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- Title
Intravitreal Conbercept Injection as an Adjuvant in Vitrectomy with Silicone Oil Infusion for Severe Proliferative Diabetic Retinopathy.
- Authors
Gao, Shuang; Lin, Zhongjing; Chen, Yanwei; Xu, Jianmin; Zhang, Qiong; Chen, Jili; Shen, Xi
- Abstract
Purpose: To assess the clinical effects of preoperative, intraoperative, or preoperative combined with intraoperative intravitreal conbercept (IVC) injection in vitrectomy with silicone oil tamponade for severe proliferative diabetic retinopathy (PDR). Methods: Ninety-eight eyes of 98 severe PDR patients undergoing vitrectomy with silicone oil tamponade were randomly assigned to 3 groups: Group 1 (34 eyes) received IVC injections 3 to 5 days before surgery; Group 2 (35 eyes) received IVC injections at the end of surgery; and Group 3 (29 eyes) received IVC injections 3 to 5 days before and at the end of operation. Follow-up examinations were performed for 6 months. Results: The incidence and severity of intraoperative bleeding were not significantly different (P = 0.233). However, the duration of surgery was significantly shorter in Group 1 and Group 3 compared with Group 2 (P < 0.001). The incidences of early and late recurrent vitreous hemorrhage (VH) were 32.35%, 28.57%, and 13.80%, respectively. At 6-month follow-up, mean best-corrected visual acuity had significantly increased to 1.25 ± 0.45 logMAR in Group 1, 1.29 ± 0.46 logMAR in Group 2, 1.16 ± 0.44 logMAR in Group 3 (all P < 0.001). The incidence of postoperative VH, neovascular glaucoma, and retinal detachment in Group 3 was slightly lower, however, no significant differences were observed (all P > 0.05). In young patients, similar results were observed and Group 3 had better visual improvements (P = 0.037). Conclusions: Preoperative IVC injection could be a safe and effective adjunct in pars plana vitrectomy with silicone oil tamponade for severe PDR. Preoperative combined with intraoperative IVC are promising, especially in young patients.
- Subjects
DIABETIC retinopathy; VITRECTOMY; SILICONES; BEVACIZUMAB; INJECTIONS; VASCULAR endothelial growth factor antagonists; PREOPERATIVE care; NEOVASCULARIZATION inhibitors; GLAUCOMA; INTRAOPERATIVE care; SURGICAL complications; DISEASE incidence; EYE hemorrhage; SEVERITY of illness index; VISUAL acuity; COMBINED modality therapy; RETINAL detachment; RECOMBINANT proteins; HEMORRHAGE; LONGITUDINAL method
- Publication
Journal of Ocular Pharmacology & Therapeutics, 2020, Vol 36, Issue 5, p304
- ISSN
1080-7683
- Publication type
journal article
- DOI
10.1089/jop.2019.0149