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- Title
Fanconi anemia. Oxymetholone hepatic tumors, and chromosome aberrations associated with leukemic transition.
- Authors
Obeid, D. A.; Hill, F. G. H.; Harnden, D.; Mann, J. R.; Wood, B. S. B.; Hill, F G; Wood, B S
- Abstract
Jaundice and hepatomegaly developed in a boy with Fanconi anemia after he had undergone treatment with oxymetholone for nine years. A liver scan showed patchy uptake consistent with the presence of space-occupying lesions. After oxymetholone treatment was stopped, the jaundice resolved, the liver size decreased, and the filling defects were no longer detectable on the liver scan. A year later, 5% of his white blood cells showed a consistent chromosomal abnormality. His leukocyte count increased and 85% of these cells showed the same chromosomal abnormality. The rapid replication of this abnormal clone suggests that it was leukemic. The significance of oxymetholone therapy and the occurrence of hepatic tumors and leukemia is discussed.
- Publication
Cancer (0008543X), 1980, Vol 46, Issue 6, p1401
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(19800915)46:6<1401::AID-CNCR2820460619>3.0.CO;2-#