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- Title
Familial occurrence of colon and uterine carcinoma and of lymphoproliferative malignancies. II. Chromosomal and immunologic abnormalities.
- Authors
Law, Ivan P.; Hollinshead, Ariel C.; Whang-Peng, Jacqueline; Dean, Jack H.; Oldham, Robert K.; Herberman, Ronald B.; Rhode, Marvin C.; Law, I P; Hollinshead, A C; Whang-Peng, J; Dean, J H; Oldham, R K; Herberman, R B; Rhode, M C
- Abstract
Cytogenic and immunologic studies were performed on 20 members of a family who had an increased susceptibility to carcinomas of the colon, uterus and of lymphoproliferative malignancy. Chromosomal abnormalities such as small G and/or long submetacentric marker chromosome and other aberrations were observed in members who had cancer as well as some asymptomatic siblings. In addition, impairment of T cell function was noted in many of the members suggesting that defective cell-mediated immunity, which also may be genetically determined, played an important role in the expression of this disease.
- Subjects
CHROMOSOME abnormalities; COLON tumors; DELAYED hypersensitivity; IMMUNOLOGY technique; LYMPHOMAS; T cells; UTERINE tumors; ANTIBODY formation
- Publication
Cancer (0008543X), 1977, Vol 39, Issue 3, p1229
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(197703)39:3<1229::AID-CNCR2820390331>3.0.CO;2-J