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- Title
Effect of chronic excess iodine intake on thyroid function and oxidative stress in hypothyroid rats.
- Authors
Hussein, Abd El-Aziz M.; Abbas, Amr M.; El Wakil, Gehan A.; Elsamanoudy, Ayman Z.; El Aziz, Azza Abd
- Abstract
Our objective was to investigate the effects of chronic excess iodine intake on thyroid functions and thyroid oxidative stress state in hypothyroid rats. Sixty rats were divided into euthyroid and hypothyroid (thiocyanate-induced) groups with or without administration of excess iodine (3000 or 6000 μg/L) for 8 weeks. Serum thyroxine (T4), triiodothyronine (T3), thyroid-stimulating hormone (TSH), thyroid antioxidants (catalase, superoxide dismutase enzymes, and total antioxidants), and lipid peroxide (malondialdehyde; MDA) were measured. Reverse transcription - PCR gene expression for thyroidal Na+/I- symporter (NIS), D1 deiodinase, and thyroid peroxidase (TPO) were performed. Thiocyanate significantly decreased thyroid hormones (T3, T4), increased lipid peroxides and antioxidants, and increased gene expression of NIS, D1 deiodinase, and TPO. Excess iodine intake in hypothyroid rats increased T3 and T4. Also, high iodine intake by hypothyroid rats significantly decreased NIS, D1 deiodinase, and TPO genes expression. Excess iodine significantly increased MDA and antioxidants in euthyroid and hypothyroid rats. In conclusion, thiocyanate-hypothyroidism increases gene expression of NIS, TPO, and TPO and induces oxidative stress. High iodine intake decreases NIS and D1 deiodinase gene expression in hypothyroid rats. Moreover, excess iodine increase thyroid hormones, lipid peroxides, and antioxidants in hypothyroid rats.
- Subjects
IODINE in the body; THYROID gland function tests; OXIDATIVE stress; HYPOTHYROIDISM; LABORATORY rats; THYROID hormones; IODIDE peroxidase
- Publication
Canadian Journal of Physiology & Pharmacology, 2012, Vol 90, Issue 5, p617
- ISSN
0008-4212
- Publication type
Article
- DOI
10.1139/y2012-046