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- Title
Efficacy of Interferons on Bowenoid Papulosis and Other Precancerous Lesions.
- Authors
Gross, Gerd; Roussaki, Angelika; Papendick, Uwe
- Abstract
Preliminary results of an open randomized trial of recombinant interferon gamma in patients suffering from bowenoid papulosis are described. Recombinant interferon gamma was given subcutaneously to 12 patients at a daily dose of 4 × 106 I.U. by injection. Four patients each were assigned to one of three treatment groups consisting of continuous therapy (group A) with three subcutaneous injections per week for 13 weeks; intermittent block therapy (group B) with four six-week cycles consisting of five injections on days 1, 3, 5, 7, and 9 of each cycle; and intermittent single-dose therapy (group C) with six four-week cycles consisting of only one subcutaneous injection on day one of each cycle. At the twenty-sixth week after onset of therapy, complete responses were seen in three of four patients of treatment group A, whereas in the treatment groups B and C only one patient, respectively, responded partially. These results suggest that in contrast to condylomata acuminata bowenoid papulosis lesions respond better to continuous than to intermittent interferon gamma injections.
- Subjects
INTERFERONS; PRECANCEROUS conditions; ANTIVIRAL agents; MEDICAL research; THERAPEUTICS; GENITAL warts
- Publication
Journal of Investigative Dermatology, 1990, Vol 95, p152S
- ISSN
0022-202X
- Publication type
Article
- DOI
10.1111/1523-1747.ep12875145