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- Title
Deferasirox improves hematologic and hepatic function with effective reduction of serum ferritin and liver iron concentration in transfusional iron overload patients with myelodysplastic syndrome or aplastic anemia.
- Authors
Cheong, June‐Won; Kim, Hyeoung‐Joon; Lee, Kyoo‐Hyung; Yoon, Sung‐Soo; Lee, Jae Hoon; Park, Hee‐Sook; Kim, Ho Young; Shim, Hyeok; Seong, Chu‐Myung; Kim, Chul Soo; Chung, Jooseop; Hyun, Myung Soo; Jo, Deog‐Yeon; Jung, Chul Won; Sohn, Sang Kyun; Yoon, Hwi‐Joong; Kim, Byung Soo; Joo, Young‐Don; Park, Chi‐Young; Min, Yoo Hong
- Abstract
Background Transfusional iron overload and its consequences are challenges in chronically transfused patients with myelodysplastic syndromes ( MDSs) or aplastic anemia ( AA). Study Design and Methods This was a prospective, multicenter, open-label study to investigate the efficacy of deferasirox ( DFX) by serial measurement of serum ferritin ( S-ferritin) level, liver iron concentration ( LIC) level using relaxation rates magnetic resonance imaging, and other laboratory variables in patients with MDS or AA. Results A total of 96 patients showing S-ferritin level of at least 1000 ng/ mL received daily DFX for up to 1 year. At the end of the study, S-ferritin level was significantly decreased in MDS (p = 0.02366) and AA (p = 0.0009). LIC level was also significantly reduced by more than 6.7 mg Fe/g dry weight from baseline. Hemoglobin level and platelet counts were significantly increased from baseline (p = 0.002 and p = 0.025, respectively) for patients showing significant anemia or thrombocytopenia. Elevated alanine aminotransferase was also significantly decreased from baseline. Conclusions This study shows that DFX is effective in reducing S-ferritin and LIC level in transfusional iron overload patients with MDS or AA and is well tolerated. In addition, positive effects in hematologic and hepatic function can be expected with DFX. Iron chelation treatment should be considered in transfused patients with MDS and AA when transfusion-related iron overload is documented.
- Subjects
DEFERASIROX; BLOOD transfusion; MYELODYSPLASTIC syndromes; APLASTIC anemia; IRON in the body; MULTIPLE organ failure; MAGNETIC resonance imaging; PATIENTS; THERAPEUTICS
- Publication
Transfusion, 2014, Vol 54, Issue 6, p1542
- ISSN
0041-1132
- Publication type
Article
- DOI
10.1111/trf.12507