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- Title
The "unphysiology" of dialysis: A major cause of dialysis side effects?
- Authors
Kjellstrand, Carl M.; Evans, Robert L.; Petersen, Robert J.; Shideman, Jeffrey R.; von Hartitzsch, Barry; Buselmeier, Theodore J.
- Abstract
This article presents information on unphysiology being a major side effect of dialysis. Studies attempting to relate the side effects of hemodialysis to predialysis plasma toxin concentrations have been largely inconclusive. However, side effects have been elicited only at blood concentrations of these substances far above those seen in the hemodialyzed patient. Results of clinical trials designed to raise or lower the plasma concentrations of middle molecules, and to relate the calculated changes in their concentration to side effects, have been confusing but have generally tended to refute the middle molecule hypothesis.
- Subjects
DIALYSIS (Chemistry); HEMODIALYSIS; MEDICAL research; THERAPEUTICS; HYPOTHESIS; CLINICAL trials
- Publication
Kidney International Supplement, 1975, Issue 2, pS-30
- ISSN
0098-6577
- Publication type
Article
- DOI
10.1111/1523-1755.ep17665860