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- Title
Detection of varicella-zoster virus nucleic acid in neurons of normal human thoracic ganglia.
- Authors
Gilden, Donald H.; Rozenman, Yaacov; Murray, Ronald; Devlin, Mary; Vafai, Abbas
- Abstract
Tissue sections from four normal human thoracic ganglia were hybridized in situ with a varicella-zoster virus-RNA probe. Varicella-zoster virus was detected in two of four ganglia, localized exclusively in neurons. The detection of latent varicella-zoster virus genetic material in thoracic ganglia provides further evidence of varicella-zoster virus latency at multiple levels of the human neuraxis and supports the notion that the neuron is the primary site of herpesvirus latency.
- Publication
Annals of Neurology, 1987, Vol 22, Issue 3, p377
- ISSN
0364-5134
- Publication type
Article
- DOI
10.1002/ana.410220315