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- Title
Common variation at 3p22.1 and 7p15.3 influences multiple myeloma risk.
- Authors
Broderick, Peter; Chubb, Daniel; Johnson, David C; Weinhold, Niels; Försti, Asta; Lloyd, Amy; Olver, Bianca; Ma, Yussanne P; Dobbins, Sara E; Walker, Brian A; Davies, Faith E; Gregory, Walter A; Child, J Anthony; Ross, Fiona M; Jackson, Graham H; Neben, Kai; Jauch, Anna; Hoffmann, Per; Mühleisen, Thomas W; Nöthen, Markus M
- Abstract
To identify risk variants for multiple myeloma, we conducted a genome-wide association study of 1,675 individuals with multiple myeloma and 5,903 control subjects. We identified risk loci for multiple myeloma at 3p22.1 (rs1052501 in ULK4; odds ratio (OR) = 1.32; P = 7.47 × 10?9) and 7p15.3 (rs4487645, OR = 1.38; P = 3.33 × 10?15). In addition, we observed a promising association at 2p23.3 (rs6746082, OR = 1.29; P = 1.22 × 10?7). Our study identifies new genomic regions associated with multiple myeloma risk that may lead to new etiological insights.
- Subjects
MULTIPLE myeloma; COMPARATIVE genomics; CONFIDENCE intervals; LINKAGE disequilibrium; META-analysis; GENETICS
- Publication
Nature Genetics, 2012, Vol 44, Issue 1, p58
- ISSN
1061-4036
- Publication type
Article
- DOI
10.1038/ng.993