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- Title
Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL).
- Authors
Franke, Andre; Balschun, Tobias; Sina, Christian; Ellinghaus, David; Häsler, Robert; Mayr, Gabriele; Albrecht, Mario; Wittig, Michael; Buchert, Eva; Nikolaus, Susanna; Gieger, Christian; Wichmann, H. Erich; Sventoraityte, Jurgita; Kupcinskas, Limas; Onnie, Clive M.; Gazouli, Maria; Anagnou, Nicholas P.; Strachan, David; McArdle, Wendy L.; Mathew, Christopher G.
- Abstract
We performed a genome-wide association analysis of 1,897,764 SNPs in 1,043 German ulcerative colitis (UC) cases and 1,703 controls. We discovered new associations at chromosome 7q22 (rs7809799) and at chromosome 22q13 in IL17REL (rs5771069) and confirmed these associations in six replication panels (2,539 UC cases and 5,428 controls) from different regions of Europe (overall study sample Prs7809799 = 8.81 × 10−11 and Prs5771069 = 4.21 × 10−8, respectively).
- Subjects
EUROPE; GENOMES; ULCERATIVE colitis; CHROMOSOME abnormalities; VIRAL replication
- Publication
Nature Genetics, 2010, Vol 42, Issue 4, p292
- ISSN
1061-4036
- Publication type
Article
- DOI
10.1038/ng.553