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- Title
A nonsynonymous functional variant in integrin-α<sub>M</sub> (encoded by ITGAM) is associated with systemic lupus erythematosus.
- Authors
Nath, Swapan K.; Shizhong Han; Kim-Howard, Xana; Kelly, Jennifer A.; Viswanathan, Parvathi; Gilkeson, Gary S.; Wei Chen; Cheng Zhu; McEver, Rodger P.; Kimberly, Robert P.; Alarcón-Riquelme, Marta E.; Vyse, Timothy J.; Quan-Zhen Li; Wakeland, Edward K.; Merrill, Joan T.; James, Judith A.; Kaufman, Kenneth M.; Guthridge, Joel M.; Harley, John B.
- Abstract
We identified and replicated an association between ITGAM (CD11b) at 16p11.2 and risk of systemic lupus erythematosus (SLE) in 3,818 individuals of European descent. The strongest association was at a nonsynonymous SNP, rs1143679 (P = 1.7 × 10−17, odds ratio = 1.78). We further replicated this association in two independent samples of individuals of African descent (P = 0.0002 and 0.003; overall meta-analysis P = 6.9 × 10−22). The genetic association between ITGAM and SLE implicates the αMβ2-integrin adhesion pathway in disease development.
- Subjects
CELL adhesion molecules; SYSTEMIC lupus erythematosus; AUTOIMMUNE diseases; VASCULAR diseases; META-analysis
- Publication
Nature Genetics, 2008, Vol 40, Issue 2, p152
- ISSN
1061-4036
- Publication type
Article
- DOI
10.1038/ng.71