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- Title
Characterization of a Bovine Thymic Differentiation Antigen Analogous to CD1 in the Human.
- Authors
MacHugh, N. D.; Bensaid, A.; Davis, W. C.; Howard, C. J.; Parsons, K. R.; Jones, B.; Kaushal, A.
- Abstract
Three monoclonal antibodies (MoAb), TH97A, CC13, and CC14, define a thymic differentiation antigen in cattle, The antigen is expressed on 50–60% of bovine thymocytes, located mainly in the cortical areas, but is not expressed on peripheral blood mononuclear cells (PBMC). In cryostat sections of lymph node, the antibodies react with large dendritic-like cells in the paracortical regions. They also react with a proportion of the large ‘frilly’ cells in afferent lymph and with dendritic-like tells in the dermis. The antibodies apparently do not react with cells in the epidermis. Biochemical analysis of the antigen recognized by MoAb TH97 A reveals two bands of 44 kDa and 12 kDa under reducing conditions. These polypeptides are distinct from bovine class I major histocompatibility complex molecules reactive with the MoAb w6/32. The tissue distribution of positive cells together with results of biochemical analyses indicate that the antigen recognized by these MoAb is the bovine analogue of the human CD1.
- Subjects
MONOCLONAL antibodies; THYMIC hormones; ANTIGENS; DENDRITIC cells; BLOOD cells; LYMPH nodes; HLA histocompatibility antigens
- Publication
Scandinavian Journal of Immunology, 1988, Vol 27, Issue 5, p541
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1988.tb02381.x