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- Title
IgM--Induced Specific Antibody Responses: Direct Correlation between Responsiveness and Natural or Induced Recurrence of the Idiotype.
- Authors
Ivars, F.; Holmberg, D.; Cazenave, P.-A.; Coutinho, A.
- Abstract
The idiotype (Id) expressed on antibodies of the trinitrophenol (TNP)-specific BALB/c hybridoma TNP, 11 is defined as a 'nonrecurrent' or private Id in BALB/c mice, whereas the analysis of splenic plaque-forming cells (PFC) and circulating antibody in DBA/2 mice immunized with TNP antigens revealed that TNP,11 is a 'recurrent' Id in this strain. TNP,11 antibodies were characterized by their ability to induce an antigen-independent anti-TNP response in these two strains. Whereas this antibody was negative in BALB/c mice [18], a clear cut increase in splenic anti-TNP PFC, preferentially expressing the TNP,11 Id, was observed in DBA/2 mice. This correlation between Id recurrency and ability to induce antigen-independent responsed was further probed in BALB/c mice repeatedly immunized with anti-TNP, Id antibodies (Ab3), Such BALB/c mice express the TNP,11 Id in detactable amounts even without antigen challenge and repond with increased numbers of splenic anti-TNP PFC to the injection of low amounts of TNP,11 antibody. These findings suggest that the ability of an antibody to induce antigen-independent PFC responses is associated with the 'recurrency', either natural or induced, of the antibody Id.
- Subjects
HYBRIDOMAS; IMMUNOGLOBULIN idiotypes; CELLS; ANTIGENS; IMMUNITY; LYMPHOCYTES; NITROPHENOLS
- Publication
Scandinavian Journal of Immunology, 1983, Vol 17, Issue 3, p231
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1983.tb00786.x