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- Title
Enhancement of Human B Lymphocyte Differentiation in Vitro by Thyroid Hormone.
- Authors
Paavonen, T.
- Abstract
A study was made of the regulatory influence of a thyroid hormone, triiodothyronine (Ta), on human blood T- and B-lymphocyte responses in vitro. Blood lymphocytes were stimulated with the T-cell mitogens concanavalin A (Con A) and phytohaemagglutinin (PHA), with the T-dependent B-cell activator pokeweed mitogen (PWM), and with the T-independent B-cell activator Staphylococcus aureus Cowan I bacteria in the presence of various hormone concentrations. T3 did not stimulate T-cell proliferation. The number of immunoglobulin-containing and -secreting cells (plasmablasts) was increased in PWM and Staph. aureus cultures treated with T3. The maximal enhancement was reached at a concentration of 10-9-10-7 M T3. Cell fractionation techniques revealed that T3 apparently had a direct stimulatory effect on B-cell differentiation.
- Subjects
TRIIODOTHYRONINE; THYROID hormones; T cells; B cells; MITOGENS; CELL differentiation
- Publication
Scandinavian Journal of Immunology, 1982, Vol 15, Issue 2, p211
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1982.tb00640.x