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- Title
Role of Ubiquilin-2 in Proteostasis and Tau Aggregation in Tauopathies.
- Authors
Yuxing Xia
- Abstract
The article discusses the group of neurologic disorders that include frontotemporal dementia (FTD) and Alzheimer's disease (AD). Topics include the hallmark of tauopathies is the accumulation of toxic aggregates composed of hyperphosphorylated tau protein throughout the CNS; neurofibrillary tangles, directly correlate with the clinical progression of cognitive decline, and effects of UBQLN2 on tau levels were further confirmed in mouse models of tauopathy.
- Subjects
TAU proteins; TAUOPATHIES; HSP70 heat-shock proteins; FRONTOTEMPORAL lobar degeneration
- Publication
Journal of Neuroscience, 2022, Vol 42, Issue 32, p6168
- ISSN
0270-6474
- Publication type
Article
- DOI
10.1523/JNEUROSCI.0839-22.2022