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- Title
CYP7B1 as a Biomarker for Prostate Cancer Risk and Progression: Metabolic and Oncogenic Signatures (Diagnostic Immunohistochemistry Analysis by Tissue Microarray in Prostate Cancer Patients—Diamond Study).
- Authors
Russo, Giorgio Ivan; Durukan, Emil; Asmundo, Maria Giovanna; Lo Giudice, Arturo; Salzano, Serena; Cimino, Sebastiano; Rescifina, Antonio; Fode, Mikkel; Abdelhameed, Ali Saber; Caltabiano, Rosario; Broggi, Giuseppe
- Abstract
We aimed to analyze the association between CYP7B1 and prostate cancer, along with its association with proteins involved in cancer and metabolic processes. A retrospective analysis was performed on 390 patients with prostate cancer (PC) or benign prostatic hyperplasia (BPH). We investigated the interactions between CYP7B1 expression and proteins associated with PC and metabolic processes, followed by an analysis of the risk of biochemical recurrence based on CYP7B1 expression. Of the 139 patients with elevated CYP7B1 expression, 92.8% had prostate cancer. Overall, no increased risk of biochemical recurrence was associated with CYP7B1 expression. However, in a non-diabetic subgroup analysis, higher CYP7B1 expression indicated a higher risk of biochemical recurrence, with an HR of 1.78 (CI: 1.0–3.2, p = 0.05). PC is associated with elevated CYP7B1 expression. In a subgroup analysis of non-diabetic patients, elevated CYP7B1 expression was associated with an increased risk of biochemical recurrence, suggesting increased cancer aggressiveness.
- Subjects
PROSTATE cancer patients; DIAGNOSTIC immunohistochemistry; PROSTATE cancer; DISEASE risk factors; TISSUE analysis; PROSTATE-specific antigen; ANDROGEN receptors
- Publication
International Journal of Molecular Sciences, 2024, Vol 25, Issue 9, p4762
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms25094762