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- Title
The Link Between Periodontitis/Peri-implantitis and Cardiovascular Disease: A Systematic Literature Review.
- Authors
Froum, Stuart J.; Hengjeerajaras, Parnward; Kuan-You Liu; Maketone, Panpicha; Patel, Viraj; Ye Shi
- Abstract
A link between periodontitis and cardiovascular disease has been reported in the literature. For this systematic review, the keywords "cardiovascular disease" (CVD) were combined with "periodontitis" and "peri-implantitis" and were used to search for literature published on MEDLINE and PubMed between 1990 and 2020. Hand searching was also performed. A total of 206 articles were identified, 51 of which were reviewed. A link between periodontal disease and CVD can be explained by both the infection and inflammatory pathways. Interventional studies on the treatment of periodontal disease related to CVD have shown conflicting results. Therefore, based on published studies, CVD should presently be considered a comorbidity of periodontitis (with an association but no direct cause and effect documented). The association of CVD with peri-implantitis has too few studies to draw any conclusions. More studies are necessary before any conclusions can be made between CVD and periodontitis and CVD and peri-implantitis regarding possible links and the extent of association.
- Subjects
CARDIOVASCULAR diseases; PERIODONTITIS; PERI-implantitis; DENTAL implants; DISEASE prevalence; DISEASE risk factors
- Publication
International Journal of Periodontics & Restorative Dentistry, 2020, Vol 40, Issue 6, pe229
- ISSN
0198-7569
- Publication type
Article
- DOI
10.11607/prd.4591