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- Title
Effect of F, Cl, Br and I substitution on the BphB enzyme for the degradation of halogenated biphenyls, revealed by quantum and molecular mechanics.
- Authors
Zhang, Ruiming; Zhuang, Tao; Zhang, Qingzhu; Wang, Wenxing
- Abstract
Halogenated biphenyls are worldwide persistent pollutants of great environmental concern. In particular, polychlorinated biphenyls and polybrominated biphenyls have been globally used for industrial purposes until they were found highly toxic, mutagenic and carcinogenic to humans. Therefore, ecological strategies to remove halogenated biphenyls, such as enzyme-catalyzed degradation, are needed. Here, we studied the effect of substitution of F, Cl, Br or I at the 4,4′-positions of 2,3-dihydro-2,3-dihydroxybiphenyl-2,3-dehydrogenase (BphB) on the degradation of halogenated biphenyls by quantum and molecular mechanics. Results show that Boltzmann-weighted average degradation barriers of substituted BphB are all lower than the unsubstituted biphenyl, except for chlorinated biphenyl. The roles of residues nearby the active site, e.g., isoleucine89, asparagine115, serine142, asparagine143, proline184, methionine187 and threonine189, were also investigated.
- Subjects
BIPHENYL compounds; QUANTUM mechanics; POLYCHLORINATED biphenyls; POLLUTANTS; PERSISTENT pollutants; POLYBROMINATED biphenyls
- Publication
Environmental Chemistry Letters, 2019, Vol 17, Issue 2, p1167
- ISSN
1610-3653
- Publication type
Article
- DOI
10.1007/s10311-019-00873-1