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- Title
Bipolar disorder: from families to genes.
- Authors
Alda, Martin; Alda, M
- Abstract
<bold>Background: </bold>Genetic factors are known to contribute to the etiology of bipolar illness, but the actual genetic mechanisms remain to be clarified.<bold>Methods: </bold>This paper reviews the research undertaken to establish the genetic basis of bipolar illness and to elucidate the nature of its genetic predisposition.<bold>Results: </bold>The presented findings suggest that bipolar affective disorder is a heterogeneous condition characterized by a complex relationship between the genetic susceptibility and the clinical presentation. Linkage studies have generated promising and replicated findings on chromosomes 18 and 21.<bold>Conclusion: </bold>In spite of the methodological difficulties inherent in the genetic study of psychiatric disorders recent investigations have made important advances and promise to identify specific susceptibility genes.
- Subjects
BIPOLAR disorder; GENETICS; CHROMOSOMES; MENTAL depression; AFFECTIVE disorders; PSYCHOSES; SCHIZOPHRENIA; ALCOHOLISM; PATHOLOGICAL psychology; DIAGNOSIS of bipolar disorder; COMPARATIVE studies; RESEARCH methodology; MEDICAL cooperation; RESEARCH; PHENOTYPES; EVALUATION research; PSYCHOLOGY
- Publication
Canadian Journal of Psychiatry, 1997, Vol 42, Issue 4, p378
- ISSN
0706-7437
- Publication type
journal article
- DOI
10.1177/070674379704200404