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- Title
Acid‐Catalyzed RNA‐Oligomerization from 3',5'‐cGMP.
- Authors
Wunnava, Sreekar; Dirscherl, Christina F.; Výravský, Jakub; Kovařík, Aleš; Matyášek, Roman; Šponer, Jiří; Braun, Dieter; Šponer, Judit E.
- Abstract
The assembly of ancient informational polymers from nucleotide precursors is the central challenge of life's origin on our planet. Among the possible solutions, dry polymerization of 3',5'‐cyclic guanosine monophosphate (3',5'‐cGMP) has been proposed as a candidate to create oligonucleotides of 15–20 units in length. However, the reported sensitivity of the reaction to the presence of cations raised questions of whether this chemistry could be relevant in a geological context. The experiments in this study show that the presence of cations is not restrictive as long as the reaction is conducted in an acidic environment, in contrast to previous reports that suggested optimal conditions at pH 9.
- Subjects
ORIGIN of life; GUANYLIC acid; ORIGIN of planets; OLIGONUCLEOTIDES
- Publication
Chemistry - A European Journal, 2021, Vol 27, Issue 70, p17581
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.202103672