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- Title
Tissue chaperoning—the expanded functions of fetuin-A beyond inhibition of systemic calcification.
- Authors
Rudloff, Stefan; Jahnen-Dechent, Willi; Huynh-Do, Uyen
- Abstract
Traditionally, fetuin-A embodies the prototype anti-calcification protein in the blood, preventing cardiovascular calcification. Low serum fetuin-A is generally associated with mineralization dysbalance and enhanced mortality in end stage renal disease. Recent evidence indicates that fetuin-A is a crucial factor moderating tissue inflammation and fibrosis, as well as a systemic indicator of acute inflammatory disease. Here, the expanded function of fetuin-A is discussed in the context of mineralization and inflammation biology. Unbalanced depletion of fetuin-A in this context may be the critical event, triggering a vicious cycle of progressive calcification, inflammation, and tissue injury. Hence, we designate fetuin-A as tissue chaperone and propose the potential use of exogenous fetuin-A as prophylactic agent or emergency treatment in conditions that are associated with acute depletion of endogenous protein.
- Subjects
CHRONIC kidney failure; CALCIFICATION; BLOOD proteins; EMERGENCY medical services
- Publication
Pflügers Archiv: European Journal of Physiology, 2022, Vol 474, Issue 8, p949
- ISSN
0031-6768
- Publication type
Article
- DOI
10.1007/s00424-022-02688-6