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- Title
Fetal Transfusion of Red Blood Cells for Alloimmunization: Validity of a Published Equation.
- Authors
Ray, Camille Le; Hudon, Lynda; Leduc, Line
- Abstract
Objective: To validate the equation published in 1990 by Leduc et al. for red blood cell fetal transfusion where fetoplacental blood volume (VO) = 100 ml/kg, then improve its precision. Methods: We reviewed 101 fetal transfusions among 32 patients. We analyzed risk factors for an inaccurate estimation with uni- and multivariate analysis. We compared the obtained Leduc formula with three other published equations. Results: Fetal weight and gestational age were risk factors for an inaccurate estimation of the final Hct. Before 32 weeks the estimation of VO was 120 ml/kg instead of 100 ml/kg. All formulae overestimated the mean expected Hct value. However, expected Hct estimated by Leduc’s formula is the nearest of the observed final Hct. Conclusion: Leduc’s equation seems to be accurate, but less so for the youngest fetuses. We propose an adapted formula VO according to gestational age and fetal weight estimation. Copyright © 2009 S. Karger AG, Basel
- Subjects
PLACENTAL function tests; FETUS; GESTATIONAL age; PREGNANCY; BLOOD circulation
- Publication
Fetal Diagnosis & Therapy, 2009, Vol 25, Issue 4, p379
- ISSN
1015-3837
- Publication type
Article
- DOI
10.1159/000236150