We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Real-World Therapeutic Outcomes of S-1 Adjuvant Chemotherapy for pStage II/III Gastric Cancer in the Elderly.
- Authors
Kunisaki, Chikara; Sato, Sho; Tsuchiya, Nobuhiro; Kubo, Hirokazu; Watanabe, Jun; Sato, Tsutomu; Takeda, Kazuhisa; Tamura, Yuko; Kasahara, Kohei; Kosaka, Takashi; Akiyama, Hirotoshi; Endo, Itaru
- Abstract
Background: The predictive factors for discontinuation of S-1 administration and prognostic factors in elderly patients with pStage II/III gastric cancer receiving S-1 adjuvant chemotherapy remain unclear. Methods: Between January 2004 and December 2016, 80 elderly gastric cancer patients (≥70 years) undergoing curative D2 gastrectomy were enrolled in this study. Predictive factors for completion of S-1 administration over 1 year, adverse events due to S-1 administration, and prognostic factors for overall survival (OS) and relapse-free survival (RFS) were evaluated. Results: Twenty-eight patients (35%) completed 8 courses of S-1. The median relative dose intensity was 82.1% (IQR 31.1–100%). The incidence rates of hematological and nonhematological adverse events were acceptable. Distal gastrectomy was an independent predictive factor for completion of S-1 administration (odds ratio [OR] 0.364; 95% confidence interval [CI] 0.141–0.939; p = 0.037). Higher postoperative neutrophil count/lymphocyte count (N/L) ratio and more advanced stage adversely influenced OS. Multivariate analysis revealed that a higher postoperative N/L ratio and more advanced stage adversely affected RFS. Conclusion: To complete adjuvant S-1 administration to elderly patients with pStage II/III gastric cancer, total gastrectomy should be avoided if possible. A new regimen for elderly gastric cancer patients with higher postoperative N/L ratios and more advanced stage should be established.
- Subjects
STOMACH cancer; ADJUVANT chemotherapy; OLDER people; PROGNOSIS; OVERALL survival; LYMPHOCYTE count
- Publication
European Surgical Research, 2021, Vol 62, Issue 1, p40
- ISSN
0014-312X
- Publication type
Article
- DOI
10.1159/000515175