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- Title
Involvement of IL-18 and Soluble Fas in Patients with Postoperative Hepatic Failure.
- Authors
H. Nakae; Y.-J. Zheng; H. Wada; K. Tajimi; S. Endo
- Abstract
AbstractWe measured the levels of tumor necrosis factor alpha (TNF-α), interleukins (IL)-6 and -18, and soluble Fas (sFas) in 11 patients with postoperative hepatic failure and assessed whether IL-18-mediated apoptosis is involved in the onset of liver dysfunction. The serum TNF-α, IL-18, and sFas levels were significantly higher in patients with sepsis as a complication than in those without sepsis. The TNF-α and IL-18 levels were significantly higher in nonsurvivors than in survivors. Significant correlations were observed between TNF-α and IL-6, between TNF-α and IL-18, and between TNF-α and sFas levels. These results showed that Fas-mediated hepatocyte apoptosis functions as an important mechanism responsible for the onset of postoperative hepatic failure in humans. They especially suggested that IL-18 and TNF-α function both as apoptosis-promoting factors and as apoptosis-inhibiting factors, depending on the conditions to which hepatocytes are subjected.Copyright © 2003 S. Karger AG, Basel
- Subjects
TUMOR necrosis factors; APOPTOSIS; INTERLEUKINS; LIVER failure; LIVER cells
- Publication
European Surgical Research, 2003, Vol 35, Issue 2, p61
- ISSN
0014-312X
- Publication type
Article
- DOI
10.1159/000069395