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- Title
Abnormalities in the Enamel in Bmp2-Deficient Mice.
- Authors
Junsheng Feng; Yang, Guobin; Yuan, Guohua; Gluhak-Heinrich, Jelica; Yang, Wuchen; Wang, Lynn; Zhi Chen; Schulze McDaniel, Jennifer; Donly, Kevin J.; Harris, Stephen E.; MacDougall, Mary; Shuo Chen
- Abstract
Tooth development is regulated by epithelial-mesenchymal interactions and their reciprocal molecular signaling. Bone morphogenetic protein 2 (Bmp2) is essential for tooth formation. However, the role of Bmp2 during enamel formation remains unknown in vivo. In this study, the role of Bmp2 in the regulation of postnatal enamel formation was investigated via the conditional ablation of Bmp2 in enamel using the (Osx-Cre) mouse. Bmp2 gene ablation was confirmed by PCR analysis in Osx-Cre, Bmp2flox/flox mice. Bmp2-null mice displayed a severe and profound tooth phenotype with asymmetric and open forked incisors. Microradiographs revealed broken incisor tips and dental pulp chamber exposure. The enamel layer of incisors and molars was thin with hypomineralization. Scanning electron microscopy analysis showed that the enamel surface was rough with chipping and the enamel lacked a typical prismatic architecture. These results demonstrate that Bmp2 is essential for enamel formation. Copyright © 2011 S. Karger AG, Basel
- Subjects
DENTITION; BONE morphogenetic proteins; DENTAL enamel; TOOTH demineralization; SCANNING electron microscopy; MESENCHYMAL stem cells; LABORATORY mice
- Publication
Cells Tissues Organs, 2011, Vol 194, Issue 2-4, p216
- ISSN
1422-6405
- Publication type
Article
- DOI
10.1159/000324644